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neurology

Traumatic Head Injury

Head injury ranges from minor (GCS 14–15, no LOC) to severe (GCS ≤8). Primary injury occurs at impact; secondary injury (from hypoxia, hypotension, rising ICP) is preventable. Maintain airway, oxygenation, and normotension to prevent secondary…

NICE NG232 Head Injury Pathway

The pathway

1 · Primary survey (ATLS)

2 · GCS assessment

3 · CT head — within 1 hour

4 · CT head — within 8 hours

LOC or amnesia plus any one of:

Do not refer for imaging by direct access from the community.

5 · On an anticoagulant or antiplatelet?

6 · Pupils

7 · Prevent secondary injury

8 · Neurosurgical referral

An isolated simple linear closed non-depressed skull fracture, in someone not anticoagulated, does not by itself require admission.

9 · C-spine clearance

10 · Before they go home

Drugs

DrugDoseRouteNotes
Mannitol 20%0.25–0.5g/kgIVFor raised ICP/herniation signs. Senior/neurosurgical guidance required.
Tranexamic acid — ISOLATED head injury2g IV bolus (no infusion)IVGCS ≤12 with no active extracranial bleeding. Give within 2 hours, before imaging. Different from the major trauma regimen — do not confuse the two.
Tranexamic acid — MAJOR TRAUMA1g over 10 min, then 1g over 8hIVMultiple injuries with bleeding. Within 3 hours. The infusion is part of this regimen and not part of the isolated head injury one.
Levetiracetam500mg–1g BDIV/POPost-traumatic seizure prophylaxis in severe TBI (7 days).

When to escalate

GCS ≤8 — consider intubation, neurosurgical ITU,Blown pupil — immediate neurosurgery,CT: extradural or expanding subdural haematoma,Deteriorating GCS — repeat CT immediately,Cushing's triad (hypertension, bradycardia, irregular breathing) = severe raised ICP,Persistent hyponatraemia or hypotension after a head injury — consider hypopituitarism (NG232 1.9.7)

Reference: NICE NG232 Head injury: assessment and early management (2023, replaced CG176) / ATLS

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