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neurology
Traumatic Head Injury
Head injury ranges from minor (GCS 14–15, no LOC) to severe (GCS ≤8). Primary injury occurs at impact; secondary injury (from hypoxia, hypotension, rising ICP) is preventable. Maintain airway, oxygenation, and normotension to prevent secondary…
NICE NG232 Head Injury Pathway
The pathway
1 · Primary survey (ATLS)
- Airway with c-spine control
- Breathing
- Circulation
- Disability — GCS, pupils
- Exposure
- Assume c-spine injury until cleared
2 · GCS assessment
3 · CT head — within 1 hour
4 · CT head — within 8 hours
LOC or amnesia plus any one of:
- Age ≥65
- Bleeding or clotting disorder
- Dangerous mechanism — pedestrian or cyclist vs vehicle, ejection, fall >1m or 5 stairs
- >30 min retrograde amnesia
Do not refer for imaging by direct access from the community.
5 · On an anticoagulant or antiplatelet?
- Applies to warfarin, DOACs, heparin, LMWH and antiplatelets — not aspirin alone
- CG176 said scan everyone. NG232 says CONSIDER, and widened the group
- Within 8 hours of injury, or within 1 hour if presenting >8 hours after
- GCS 15, no LOC, no amnesia, nothing else: can be risk assessed instead — a shared decision
- LOC and amnesia are the features that matter (AHEAD). Scan if you cannot risk assess reliably, or if they may not come back
6 · Pupils
- Unequal pupils — blown pupil suggests uncal herniation, a neurosurgical emergency
- Fixed dilated pupils suggest brainstem compression
7 · Prevent secondary injury
- SpO₂ >95%
- SBP >90, or MAP >70 in severe TBI
- Avoid hyperthermia
- Treat seizures
- BM 5–10 mmol/L
- Head of bed 30°
8 · Neurosurgical referral
- Extradural: lens-shaped, often a lucid interval — emergency
- Subdural: crescent-shaped, often elderly on anticoagulants
- Depressed skull fracture
An isolated simple linear closed non-depressed skull fracture, in someone not anticoagulated, does not by itself require admission.
9 · C-spine clearance
- NEXUS or Canadian C-Spine Rule
- CT c-spine for high risk — and also for medium risk in adults
- No role for plain X-rays in adults
- Rigid collar until cleared
10 · Before they go home
- Written and verbal head injury advice, with someone to supervise
- Pre-injury cognitive impairment or custodial setting: check supervision is actually arranged
- Any severity can cause pituitary dysfunction — immediately, or months later. Persistent hyponatraemia or hypotension: consider hypopituitarism
- Consider a falls assessment or safeguarding referral
Drugs
| Drug | Dose | Route | Notes |
|---|---|---|---|
| Mannitol 20% | 0.25–0.5g/kg | IV | For raised ICP/herniation signs. Senior/neurosurgical guidance required. |
| Tranexamic acid — ISOLATED head injury | 2g IV bolus (no infusion) | IV | GCS ≤12 with no active extracranial bleeding. Give within 2 hours, before imaging. Different from the major trauma regimen — do not confuse the two. |
| Tranexamic acid — MAJOR TRAUMA | 1g over 10 min, then 1g over 8h | IV | Multiple injuries with bleeding. Within 3 hours. The infusion is part of this regimen and not part of the isolated head injury one. |
| Levetiracetam | 500mg–1g BD | IV/PO | Post-traumatic seizure prophylaxis in severe TBI (7 days). |
When to escalate
GCS ≤8 — consider intubation, neurosurgical ITU,Blown pupil — immediate neurosurgery,CT: extradural or expanding subdural haematoma,Deteriorating GCS — repeat CT immediately,Cushing's triad (hypertension, bradycardia, irregular breathing) = severe raised ICP,Persistent hyponatraemia or hypotension after a head injury — consider hypopituitarism (NG232 1.9.7)
Reference: NICE NG232 Head injury: assessment and early management (2023, replaced CG176) / ATLS
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